MADI Publications

Pasetti MF, Ackerman ME, Hoen AG, Alter G, Tsang JS, Marchant A. Maternal determinants of infant immunity: Implications for effective immunization and maternal-child health. Vaccine. 2020 June 9;38(28):4491-4494. PubMed PMID: 32111530; PubMed Central PMCID: PMC9946685; DOI: 10.1016/j.vaccine.2020.01.056.

Crowley AR, Natarajan H, Hederman AP, Bobak CA, Weiner JA, Wieland-Alter W, Lee J, Bloch EM, Tobian AAR, Redd AD, Blankson JN, Wolf D, Goetghebuer T, Marchant A, Connor RI, Wright PF, Ackerman ME. Boosting of cross-reactive antibodies to endemic coronaviruses by SARS-CoV-2 infection but not vaccination with stabilized spike. Elife. 2022 Mar 15;11:e75228. doi: 10.7554/eLife.75228. PMID: 35289271; PMCID: PMC8923670.

Backes IM, Leib DA, Ackerman ME. Monoclonal antibody therapy of herpes simplex virus: An opportunity to decrease congenital and perinatal infections. Frontiers in immunology. 2022;13:959603. PubMed PMID: 36016956; PubMed Central PMCID: PMC9398215; DOI: 10.3389/fimmu.2022.959603.

Jennewein MF, Kosikova M, Noelette FJ, Radvak P, Boudreau CM, Campbell JD, Chen WH, Xie H, Alter G, Pasetti MF. Functional and structural modifications of influenza antibodies during pregnancy. iScience. 2022 April 15;25(4):104088. PubMed PMID: 35402869; PubMedCentral PMCID: PMC8991102; DOI: 10.1016/j.isci.2022.104088.

Taylor SA, Sharma S, Remmel CAL, Holder B, Jones CE, Marchant A, Ackerman ME. HIV-Associated Alterations of the Biophysical Features of Maternal Antibodies Correlate With Their Reduced Transfer Across the Placenta. The Journal of infectious diseases. 2022 October 17;226(8):1441-1450. PubMed PMID: 35668706; PubMed Central PMCID: PMC9574667;DOI: 10.1093/infdis/jiac222.

Backes IM, Byrd BK, Slein MD, Patel CD, Taylor SA, Garland CR, MacDonald SW, Balazs AB, Davis SC, Ackerman ME, Leib DA. Maternally transferred mAbs protect neonatal mice from HSV-induced mortality and morbidity. The Journal of experimental medicine. 2022 December 5;219(12). PubMed PMID: 36156707; PubMed Central PMCID: PMC9516843; DOI:10.1084/jem.20220110.

Portillo S. mSphere of Influence: Pertussis Vaccination and Antibodies in Mothers and Infants. mSphere. 2023 February 21;8(1):e0000923. PubMed PMID: 36728427; PubMed Central PMCID: PMC9942552; DOI: 10.1128/msphere.00009-23.

Hederman AP, Ackerman ME. Leveraging deep learning to improve vaccine design. Trends Immunol. 2023 May;44(5):333-344. doi: 10.1016/j.it.2023.03.002. Epub 2023 Mar 30. PMID: 37003949; PMCID: PMC10485910.

Jennewein MF, Kosikova M, Noelette FJ, Radvak P, Boudreau CM, Campbell JD, Chen WH, Xie H, Alter G, Pasetti MF. Functional and structural modifications of influenza antibodies during pregnancy. iScience. 2022 Mar 16;25(4):104088. doi: 10.1016/j.isci.2022.104088. PMID: 35402869; PMCID: PMC8991102.

Lemme-Dumit JM, Song Y, Lwin HW, Hernandez-Chavez C, Sundararajan S, Viscardi RM, Ravel J, Pasetti MF, Ma B. Altered Gut Microbiome and Fecal Immune Phenotype in Early Preterm Infants With Leaky Gut. Front Immunol. 2022 Feb 23;13:815046. doi: 10.3389/fimmu.2022.815046. PMID: 35280991; PMCID: PMC8905226.

Hederman AP, Natarajan H, Heyndrickx L, Ariën KK, Wiener JA, Wright PF, Bloch EM, Tobian AAR, Redd AD, Blankson JN, Rottenstreich A, Zarbiv G, Wolf D, Goetghebuer T, Marchant A, Ackerman ME. SARS-CoV-2 vaccination elicits broad and potent antibody effector functions to variants of concern in vulnerable populations. Nat Commun. 2023 Aug 24;14(1):5171. doi: 10.1038/s41467-023-40960-0. PMID: 37620337; PMCID: PMC10449910.

Slein MD, Backes IM, Garland CR, Kelkar NS, Leib DA, Ackerman ME. Antibody effector functions are required for broad and potent protection of neonates from herpes simplex virus infection. bioRxiv [Preprint]. 2023 Aug 31:2023.08.29.555423. doi: 10.1101/2023.08.29.555423. PMID: 37693377; PMCID: PMC10491243.

Taton M, Willems F, Widomski C, Martin C, Jiang Y, Renard K, Cogan A, Necsoi C, Ackerman ME, Marchant A, Dauby N. Impact of pregnancy on polyfunctional IgG and memory B cell responses to Tdap immunization. Vaccine. 2023 Jun 19;41(27):4009-4018. doi: 10.1016/j.vaccine.2023.05.035. Epub 2023 May 25. PMID: 37244810.

Rosenberg YJ, Ordonez T, Khanwalkar US, Barnette P, Pandey S, Backes IM, Otero CE, Goldberg BS, Crowley AR, Leib DA, Shapiro MB, Jiang X, Urban LA, Lees J, Hessell AJ, Permar S, Haigwood NL, Ackerman ME. Evidence for the Role of a Second Fc-Binding Receptor in Placental IgG Transfer in Nonhuman Primates. mBio. 2023 Apr 25;14(2):e0034123. doi: 10.1128/mbio.00341-23. Epub 2023 Mar 22. PMID: 36946726; PMCID: PMC10127586.

Dubois V, Chatagnon J, Depessemier M, Locht C. Maternal acellular pertussis vaccination in mice impairs cellular immunity to Bordetella pertussis infection in offspring. JCI Insight. 2023 Sep 22;8(18):e167210. doi: 10.1172/jci.insight.167210. PMID: 37581930; PMCID: PMC10561720.

Tripathi S, Tsang JS, Park K. Systems immunology of regulatory T cells: can one circuit explain it all?. Trends in immunology. 2023 October;44(10):766-781. PubMed PMID: 37690962; PubMed Central PMCID: PMC10543564; DOI: 10.1016/j.it.2023.08.007.

Carpenter MC, Souter SC, Zipkin RJ, Ackerman ME. Current Insights Into K-associated Fetal Anemia and Potential Treatment Strategies for Sensitized Pregnancies. Transfusion medicine reviews. 2024 January;38(1):150779. PubMed PMID: 37926651; PubMed Central PMCID: PMC10856777; DOI: 10.1016/j.tmrv.2023.150779.

Nziza N, Deng Y, Wood L, Dhanoa N, Dulit-Greenberg N, Chen T, Kane AS, Swank Z, Davis JP, Demokritou M, Chitnis AP, Fasano A, Edlow AG, Jain N, Horwitz BH, McNamara RP, Walt DR, Lauffenburger DA, Julg B, Shreffler WG, Alter G, Yonker LM. Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination. Nature communications. 2024 January 30;15(1):905. PubMed PMID: 38291080; PubMed Central PMCID: PMC10827750; DOI: 10.1038/s41467-024-45181-7.

Slein MD, Backes IM, Garland CR, Kelkar NS, Leib DA, Ackerman ME. Effector functions are required for broad and potent protection of neonatal mice with antibodies targeting HSV glycoprotein D. Cell reports. Medicine. 2024 February 20;5(2):101417. PubMed PMID: 38350452; PubMed Central PMCID: PMC10897633; DOI: 10.1016/j.xcrm.2024.101417.

Portillo S, Oshinsky J, Williams M, Yoder S, Liang Y, Campbell JD, Laufer MK, Neuzil KM, Edwards KM, Pasetti MF. Quantitative analysis of pertussis, tetanus, and diphtheria antibodies in sera and breast milk from Tdap vaccinated women using a qualified multiplex assay. mSphere. 2024 Apr 23;9(4):e0052723. doi: 10.1128/msphere.00527-23. Epub 2024 Mar 18. PMID: 38497618; PMCID: PMC11036809.

Taton M, Willems F, Widomski C, Georges D, Martin C, Jiang Y, Renard K, Konopnicki D, Cogan A, Necsoi C, Matagne A, De Wit S, Ackerman ME, Marchant A, Dauby N. HIV-related immune activation attenuates polyfunctional IgG and memory B-cell responses to Tdap immunization during pregnancy. EBioMedicine. 2024 Jun;104:105179. doi: 10.1016/j.ebiom.2024.105179. Epub 2024 Jun 7. PMID: 38848615; PMCID: PMC11192781.

Nziza N, Jung W, Mendu M, Chen T, Julg B, Graham B, Ramilo O, Mejias A, Alter G. Longitudinal humoral analysis in RSV-infected infants identifies pre-existing RSV strain-specific G and evolving cross-reactive F antibodies. Immunity. 2024 Jul 9;57(7):1681-1695.e4. doi: 10.1016/j.immuni.2024.05.019. Epub 2024 Jun 13. PMID: 38876099.

Hawkins A, Pantazi P, Yang L, Coyne CB, Bokun V, Lemme-Dumit JM, Pasetti MF, Barnett S, Culley FJ, Holder B. Long-term culture and passaging of term trophoblast for the investigation of syncytiotrophoblast function. Placenta. 2024 Aug 28:S0143-4004(24)00632-5. doi: 10.1016/j.placenta.2024.08.014. Epub ahead of print. PMID: 39261115.

Hederman AP, Remmel CJ, Sharma S, Natarajan H, Weiner JA, Wrapp D, Donner C, Delforge ML, d'Angelo P, Furione M, Fornara C, McLellan JS, Lilleri D, Marchant A, Ackerman ME. Discrimination of primary and chronic cytomegalovirus infection based on humoral immune profiles in pregnancy. J Clin Invest. 2024 Aug 29:e180560. doi: 10.1172/JCI180560. Epub ahead of print. PMID: 39207860.

Sparks R*, Rachmaninoff N*, Lau WW*, Hirsch DC*, Bansal N*, Martins AJ, Chen J, Liu CC, Cheung F, Failla LE, Biancotto A, Fantoni G, Sellers BA, Chawla DG, Howe KN, Mostaghimi D, Farmer R, Kotliarov Y, Calvo KR, Palmer C, Daub J, Fouraghi L, Kreuzburg S, Treat J, Urban AK, Jones A, Romeo T, Deuitch NT, Moura NS, Weinstein B, Ferrucci L, Barron KS, Aksentijevich I, Kleinstein SH, Moir S, Townsley DM, Young NS, Frischmeyer-Guerrerio PA, Uzel G, Pinto-Patarroyo GP, Cudrici CD, Hoffmann P, Stone DL, Ombrello AK, Freeman AF, Zerbe CS, Kastner DL, Holland SM, Tsang JS. A unified metric of human immune health. Nature Medicine, https://doi.org/10.1038/s41591-024-03092-6, 2024 (* co-first authors)

Mulè MP, Martins AJ, Cheung F, Farmer R, Sellers B, Quiel JA, Jain A, Kotliarov Y, Bansal N, Chen J, Schwartzberg PL, Tsang JS. Integration of population and single-cell variations identifies a naturally adjuvanted human immune setpoint. Immunity 2024, 57 (5), 1160-1176

Apps R*, Biancotto A*, Candia J*, Kotliarov Y*, Perl S, Cheung C, Farmer R, Mule MP, Chen J, Martins AJ, Shi R, Zhou H, Bansal N, Schum P, Olnes MJ, Milanez-Almeida P, Han KL, Sellers B, Cortese M, Hagan T, Rouphael N, Pulendran B, King L, Manischewitz J, Khurana S, Golding H, van der Most RG, Dickler HB, Germain RN, Schwartzberg PL, Tsang JS. High dimensional dynamic immune response discovery reveals acute and persistent impacts of H5N1 vaccination with and without adjuvants. Cell Reports 2024, in press; (* equal contributing co-first authors)